Featured Publications

SARS-CoV-2 infection of human placenta

Stuhlmann Lab (topic: Uterine and Placental Biology)

Argueta LB, Lacko LA, Bram Y, Tada T, Carrau L, Rendeiro AF, Zhang T, Uhl S, Lubor BC, Chandar V, Gil C, Zhang W, Dodson BJ, Bastiaans J, Prabhu M, Houghton S, Redmond D, Salvatore CM, Yang YJ, Elemento O, Baergen RN, tenOever BR, Landau NR, Chen S, Schwartz RE, Stuhlmann H. Inflammatory Responses in the Placenta upon SARS-CoV-2 Infection Late in Pregnancy.  iScience. 104223  Online ahead of print (2022).

The effect of SARS-CoV-2 infection on placental function is not well understood. In this study, we analyzed placentas from women who tested positive for SARS-CoV-2 at delivery. SARS-CoV-2 genomic and subgenomic RNA as detected in 22 out of 52 placentas. Placentas from two mothers with symptomatic COVID-19 whose pregnancies resulted in adverse outcomes for the fetuses contained high levels of viral Alpha variant RNA. The RNA was localized to the trophoblasts that cover the fetal chorionic villi and that are in direct contact with maternal blood. The intervillous spaces and chorionic villi were infiltrated with maternal macrophages and T cells. Transcriptome analysis showed increased expression of chemokines and pathways associated with viral infection and inflammation. Infection of placental cultures ex vivo with live SARS-CoV-2 and with spike protein-pseudotyped lentivirus showed infection of syncytiotrophoblast and, in rare cases, endothelial cells mediated by ACE2 and Neuropilin-1. Viruses with Alpha, Beta and Delta variant spikes infected the placental cultures at significantly greater levels.

The findings show that SARS-CoV-2 infection late in pregnancy can lead to severe inflammatory responses. They further highlight the importance of preventing infections during pregnancy through vaccination, and for monitoring the health of COVID-19 mothers and their infants in order to identify possible long-term clinical impacts.

Additional publications

Cohen (Paula) Lab

  • Gray S., Santiago E.R., Chappie J.S., and Cohen P.E. Cyclin N-terminal domain-containing-1 coordinates meiotic crossover formation with cell cycle progression in a cyclin-independent manner. Cell Reports 32(1): 107858 (2020)
  • Roy J.C.L., Vitalo A., Andrew M.A., Mota-Silva E., Kovalenko M., Burch Z., Nhu A.M., Cohen P.E., Grabczyk E., Wheeler V.C., & Mouro Pinto R. Somatic CAG expansion in Huntington’s disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection. Nucleic Acids Research 49(7): 3907-3918 (2021)
  • Pereira C., Arroyo-Martinez G.A., Guo M.Z., Downey M.S., Kelly E.R., Grive K.J., Mahadevaiah S.K., Freire R., Turner J.M.A., Lyndaker A.M., Brieño-Enríquez M.A., Cohen P.E., Smolka M.B., & Weiss R.S. Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis. eLife 11:e68677 (2022)
  • Sims J.R., Faça V.M., Pereira C., Ascenção C., Comstock W., Badar J., Arroyo-Martinez G.A., Freire R., Cohen P.E., Weiss R.S. & Smolka M.B. Phosphoproteomics of ATR Signaling in Mouse Testes. eLife 11: e68648 (2022)

Cohen (Roy) Lab

  • Roy Cohen, Chinatsu Mukai, Jacquelyn L Nelson, Shoshana S Zenilman, Danielle M Sosnicki, Alexander J Travis. A genetically targeted sensor reveals spatial and temporal dynamics of acrosomal calcium and sperm acrosome exocytosis. Journal of Biological Chemistry 298: 101868 (2022)

Lee Lab

  • Li CL, Pu M, Wang W, Chaturbedi A, Emerson FJ, Lee SS. Region-specific H3K9me3 gain in aged somatic tissues in Caenorhabditis elegans. PLoS Genet. 17(9):e1009432. (2021) PMID: 34506495
  • Wang W, Chaturbedi A, Wang M, An S, Santhi Velayudhan S, Lee SS. SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity. Elife. 7. pii: e34970 (2018) PMID: 29714684

Wolfner Lab

  • McCullough, E.L.*, Whittington, E.*, Singh, A.*, Pitnick, S.**, Wolfner, M.F.** and Dorus,S.** The life history of Drosophila sperm involves molecular continuity betweenmale and female reproductive tracts. Proc. Natl. Acad. Sci., 119(11):e2119899119. (2022)
  • Allen, S.E.*, Chen, D.*, Misra, S.* and Wolfner, M.F. Seminal Metalloprotease-1.Handbook of Proteolytic Enzymes, 4th edition. Vol. 1 Metalloproteases. N. Rawlings,editor. Elsevier. In press. (2022)
  • Li et al. {Drosophila FCA consortium} FlyCell Atlas: a single cell transcriptomic atlasof the adult fruit fly. Science, 375(6584):eabk2432. (2022)
  • Amaro, I.A., Ahmed-Braimah, Y., League, G.P., Pitcher, S., Avila, F.W., Cruz, P.C.,Harrington, L.C.*, and Wolfner, M.F.* Seminal fluid proteins inducetranscriptome changes in the Aedes aegypti female lower reproductive tract, includingup-regulation of immunity-related RNAs. BMC Genomics, 22(1):896. (2021)
  • League, G.P. Degner, E.C., Pitcher, S.A., Hafezi, Y., Tennant, E., Cruz, P.C., Krishnan, R.S.,Garcia Castillo, S.S., Alfonso-Parra, C., Avila, F.W., Wolfner, M.F.*, and Harrington,L.C.* The impact of mating and sugar feeding on blood-feeding physiology andbehavior in the arbovirus vector mosquito Aedes aegypti. PLoS Neglected TropicalDiseases, 15(9):e0009815. (2021)
  • Meyer, H., Buhr, A., Callaerts, P., Scheimann, R., Wolfner, M.F., Marygold, S.J. Identification and bioinformatic analysis of neprilysin and neprilysin-likemetalloendopeptidases in Drosophila melanogaster. microPublication Biology.10.17912/micropub.biology.000410. (2021)
  • Suarez, S.S. and Wolfner, M.F. Cilia take the egg on a magic carpet ride. Proc. Natl.Acad. Sci. USA, 118(27):e2108887118 (Commentary). (2021)
  • Koreman, G.T.*, Xu, Y.*, Hu, Q.*, Zhang, Z., Allen, S.E., Wolfner, M.F., Wang, B. and Han,C. Upgraded CRISPR/Cas9 Tools for Tissue-Specific Mutagenesis in Drosophila. Proc. Natl. Acad. Sci. USA, 118(14):e2014255118. (2021)
  • Immarigeon, C., Frei, Y. Delbare, S.Y., Gligorov, D., Machado Almeida, P., Grey, J.,Nagoshi, E., Billeter, J.-C., Wolfner, M.F., Karch, F. and Maeda, R.K. (2021)Identification of a novel micro peptide and multiple secondary cell genes that modulateDrosophila male reproductive success. Proc. Natl. Acad. Sci. USA,118(15):e2001897118. (2021)
  • Allen, S.E.*, Koreman, G.T.*, Sarkar, A.*, Wang, B., Wolfner, M.F.**, and Han, C.** Versatile CRISPR/Cas9-mediated  mosaic analysis  by gRNA- induced crossing -over for unmodified genomes. PLoS Biology, 19(1):e3001061. (2021)
  • White, M.A.*, Chen, D.S.*, and Wolfner, M.F. She’s got nerve: roles of octopamine in insect female reproduction. J. Neurogenet., 28, 1-22. (2021)
  • White, M.A., Bonfini, A., Wolfner, M.F.* and Buchon, N.* Drosophila melanogastersex peptide is a key regulator of female midgut morphology and physiology. Proc. Natl.Acad. Sci. USA, 118(1):e2018112118. (2021)
  • Hu, Q., Antipova, O.A., O’Halloran, T.V. and Wolfner, M.F. X-ray fluorescencemicroscopy scanning of Drosophila oocytes and eggs. STAR Protocols, 2(1):100247. (2020)
  • Delbare, S.Y.N.*, Ahmed-Braimah, Y.H.*, Wolfner, M.F., Clark, A.G. Interactionsbetween the microbiome and mating influence the female’s transcriptional profile inDrosophila melanogaster. Scientific Reports, 10(1):18168. (2020)
  • Ahmed-Braimah, Y.H., Wolfner, M.F., and Clark, A.G. Differences in post-matingtranscriptional responses between conspecific and heterospecific matings in Drosophila.Mol. Bio. Evoln, 38, 986-999. (2021)
  • Camargo, C., Ahmed-Braimah, Y., Amaro, I.A., Harrington, L.C., Wolfner, M.F. and Avila,F. W. Mating and blood-feeding induce transcriptome changes in the femalesperm storage organs of the yellow fever mosquito Aedes aegypti. Scientific Reports,10(1): 14899. (2020)
  • Misra, S. and Wolfner, M.F. Drosophila seminal Sex Peptide associates with rival aswell as own sperm, providing SP function in polyandrous females. eLife, 9:e58322. (2020)
  • Wigby, S.*, Brown, N.C.*, Allen, S.E., Misra, S., Sepil, I., Sitnik, J.L., Clark, A.G., andWolfner, M.F. The Drosophila seminal proteome and its role in spermcompetition. Phil. Trans. Roy. Soc., 375(1813):20200072. (2020)
  • Hu, Q. and Wolfner, M.F. (2020) Regulation of TRPM activation and calcium wave initiationduring Drosophila egg activation. Mol. Repro. Dev., 87(8) 880-886. (2020)
  • Hu, Q., Duncan, F.E., Nowakowski, A.B., Antipova, O.A., Woodruff, T.K., O’Halloran, T.V.,Wolfner, M.F. Zinc dynamics during Drosophila oocyte maturation and eggactivation. iScience, 23(7):101275. (2020)
  • Sinha, S., Jones, B. Traniello, I. Bukhari, S.A., Halfon, M.S., Hofmann, H.A., Huang, S.,Katz, P., Keagy, J., Lynch, V.J., Sokolowski, M.B., Stubbs, L.J., Tabe-Bordbar, S.,
  • Wolfner, M.F., and Robinson, G.E. Behavior-Related Gene RegulatoryNetworks: A New Level of Organization in the Brain.  Proc. Natl. Acad. Sci., 117(38):23270-23279. (2020)
  • Sepil, I. Hopkins, B. Dean, R., Friedman, S., Bath, E., Swanson, B. Sandham, E., Ostridge, H.,Buehner, N., Wolfner, M.F., Konietzny, R., Thezenas, M-L., Charles, P.D., Fischer, R.,Steinhauer, J., Kessler, B.M., and Wigby, S. Ejaculate deterioration with maleage and its amelioration in Drosophila. Proc. Natl. Acad. Sci., 117(29): 17094-17103. (2020)
  • Hu, Q., Aviles-Velez, A., and Wolfner, M.F. Drosophila Plc21C is involved in calciumwave propagation during egg activation. Micropublications Biology2020:10.17912/micropub.biology.000235. (2020)
  • Sirot, L.K.* and Wolfner, M.F. “Call and response”: a case of behavioral-molecularcopulatory dialogue? Bioessays, 42(11):e2000248. (Commentary (“Ideas to Watch”)) (2020)
  • Orr, T.J., Burns, M., Hawkes, K., Holekamp, K.E., Kimmitt, A.A., Lewis, K.S., Lipshutz,S.E., Stadmauer, D., S, N.L., Wolfner, M.F. and Hayssen,V. It takes two to tango:including a female perspective in reproductive biology. Integrative Compar. Biol.,60(3):796-813. (2020)
  • Hafezi, Y., Sruba, S.R., Tarrash, S.R., Wolfner, M.F. and Clark, A.G. CRISPR mutantsof three Y chromosome genes suggest gradual evolution of fertility functions inDrosophila melanogaster. Genetics, 214(4): 977-990. (2020)
  • York-Andersen, A.H.*, Hu, Q.*, Wood, B.W., Wolfner, M.F.** and Weil, T.T.** Acalcium mediated actin redistribution at egg activation in Drosophila, Mol. Repro. Dev.,87(2): 293-304. (2020)
  • Anholt, R.R.H., O’Grady, P. Wolfner, M.F. and Harbison, S.T. Evolution of Reproductive Behavior.  Genetics (Flybook), 214(1): 49-73. (2019)
  • Pitnick, S., Wolfner, M.F., and Dorus, S. PEMS: post-ejaculation modifications tosperm. Biological Reviews, 95(2) 365-392. (2019)
  • Chen, D.S.*, Delbare, S.Y.N.*, White, S.L.*, Sitnik, J.L., Chatterjee, M., Dobell, E.L., Weiss,O.D., Clark, A.G.**, and Wolfner, M.F.** Female genetic contributions to spermcompetition in Drosophila melanogaster.  Genetics 212: 789-800. (2019)
  • Hu, Q. and Wolfner, M.F. Drosophila  Trpm mediates calcium influx during eggactivation. Proc. Natl. Acad. Sci. USA 116:18994-19000. (2019)
  • Wigby, S., Lazzaro, B.P., Suarez, S.S., Pizzari, T., and Wolfner, M.F. Reproductive/immunity effects on sperm success. Current Topics in Developmental Biology, 135:287-313. (2019)
  • Hoke, K., Bass, A., McCune, A., Regan, E., and Wolfner, M.F. Co-opting Evo-Devoconcepts for new insights into behavioural and neural diversity. J. Exp. Bio. 222(Pt 8).pii: jeb190058. (2019)
  • League, G.P., Baxter, L.L., Wolfner, M.F.* and Harrington, L.C.* Male accessorygland molecules inhibit harmonic convergence during courtship flight in the mosquito Aedes aegypti. Current Biology 29(6):R196-R197. (2019)
  • Zhang, Z., Ahmed-Braimah, Y.H., Goldberg, M.L., and Wolfner, M.F. Calcineurindependent protein phosphorylation changes during egg activation in Drosophilamelanogaster. Mol. Cell. Proteomics 18(Suppl 1):S145-S158. (2019)
  • Degner, E.C.*, Ahmed-Braimah, Y.H.*, Borziak, K., Wolfner, M.F.**, Harrington, L.C.**,and Dorus, S.** Reproductive functions and genetic architecture of the seminal fluid and sperm proteomes of the mosquito Aedes aegypti. Mol. Cell. Proteomics18(Suppl 1):S6-S22. (2019)

Johnson Lab

  • Stephens, C.S., A. Hill-Ricciuti, L. Francoeur, and P.A. Johnson. Feeding Level Is Associated with Altered Liver Transcriptome and Follicle Selection in the Hen. Biology of Reproduction 1–10. (2022)
  • Francoeur, L., C.S. Stephens, and P.A. Johnson. Ad Libitum Feeding in Broiler Breeder Hens Alters the Transcriptome of Granulosa Cells of Prehierarchal Follicles. Animals, 11: 2706. (2021)
  • Lemcke, R. A., C.S. Stephens, K.A. Hildebrandt and P. A. Johnson. Anti-Müllerian hormone type II receptor in avian follicle development. Biology of Reproduction 99(6):1227-1234 (2018)

O’Brien Lab

  • Cornes R, Sintes C, PeñaA, AlbinS, O’Brien KO, Donangelo CM. Daily intake of a functional synbiotic yogurt increases calcium absorption in young adult women. J. Nutr In Press. (2022)
  • Delaney KM, Cao Chang, Guillet R, Pressman EK, O’Brien KO. Fetal Iron Uptake from Recent Maternal Diet and Red Blood Cell Catabolism. Am J Clin Nutr Jan 31 (2022)
  • O’Brien KO. Maternal, Fetal and Placental Regulation of Placental Iron Trafficking. Placenta  Dec 24:S0143-4004(21)0067-6. (2021)
  • Best CM, Sherwood R, Novotny JA, Zhang S, Pressman EK, O’Brien KO. Vitamin D3kinetics in nonpregnant and pregnant women after a single oral dose of trideuterated vitamin D3. J Steroid Biochemistry and Molecular Biology, Feb 216:106034. (2022)
  • Barad A, Guillet R, Pressman EK, Katzman PJ, Miller RK, Darrah TH. Placental Iron Content is Lower than Previously Estimated and is Associated with Maternal Iron Status in Women at Greater Risk for Gestational Iron Deficiency and Anemia. J Nutr 152(3):737-746 (2022)
  • Tussing-Humphreys L, LaBomascus B, O’Brien K, Nemeth E, Sangkhae V, Steffen A, Elam G, Castellanso K, DeMartelly V, Ruchob R, Welke L, Hemphill N, Pezley L, McLeod A, Hirsch B, Ferrans C, Koenig MD.  Prepregnancy obesity does not impact placental iron trafficking. J Nutr 151(9):2646-54. (2021)
  • Rahmani R, Stevens E, Rackovsky N, O’Brien KO, Schwartz GJ, Weber DR. Female Sex and Obesity are Risk Factors for Impaired Calcium Intake in Youth with Type 1 Diabetes. Frontiers in Clinical Diabetes 2:723855. (2021)
  • Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O’BrienKO. Umbilical cord erythroferrone is inversely associated with hepcidin, but does not capture the most variability in iron status of neonates born to teens carrying singletons and women carrying multiples. J Nutr 4:151(9):2590-2600.  Published alongwith an editorial: Kling PJ. Ironing out the details of maternal-fetal iron trafficking: New Tools in the Toolbox. J Nutr 2021; 151(9):2509-2510. (2021)
  • Kang W, Barad, A, Clark AG, Wang Y, Gu Z, O’Brien KO. Ethnic differences in iron status: A systematic reviewand meta-analysis. Adv Nutr Res 1:12(5):1838-53. (2021)
  • Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O’Brien KO. Serum erythroferrone during pregnancy is related to erythropoietin but does not predict the risk of anemia. J Nutr 151(7):1824-33. (2021)
  • Kang W, Baer N, Ramsan M, Vermeylen, F, Stoltzfus RJ, O’Brien, KO. Iron Supplementation in anemic Zanzibari toddlers is associated with greater loss in erythrocyte iron isotope enrichment. Am J Clin Nutr 114(1):330-7. (2021)
  • Wallace TC, Bailey RL, Lappe J, O’Brien KO, Wang DD, Weaver CM. Dairy intake and bone health across the lifespan: A systematic review and expert narrative. Critical Reviews in Food Science and Nutrition. 2020; Sep 14:1-47. (2020)
  • Delaney KM, Guillet R, Pressman EK, Caulfield LE, Zavaleta N, O’Brien KO. Iron absorption during pregnancy is underestimated when iron utilization by the placenta and fetus are ignored. Am J Clin Nutr 112:576-585. (2020)
  • Koenig MD, Klikuszowian E, O’Brien KO, Pauls H, Steffen A, DeMartelly V, Ruchob R, Welke L,Hemphill N, LaBomascus B, Pezley L, McLeod A, Hirsch B, Ferrans CE, Tussing-Humphreys L. Prepregnancy Obesity is not Associated with Iron Utilization during the Third Trimester of Pregnancy. J Nutr 150(6):1397-1404. (2020)
  • Vander Wyst KB, Vercelli ME, O’Brien KO, Cooper EM, Pressman EK, Whisner CM. A social media intervention to improve nutrition knowledge and behaviors of low income, pregnant adolescents and adult women. PLoS One 14(10):e0223120. (2020)
  • Finkelstein J, Guillet R, Pressman EK, Kent TR, Guetterman HM, O’Brien KO. Vitamin B12 Status in Pregnant Adolescents and their Infants. Nutrients 11(2):397. (2019)
  • Gil-Díaz MC, Raynor J, Schwartz GJ, O’Brien KO, Weber DR. Systematic Review: Associations of Calcium Intake, Vitamin D Intake, and Physical Activity on Skeletal Outcomes in People with Type 1 Diabetes Mellitus. Acta Diabetologica 56(1):1091-1102. (2019)
  • Güngör D, Nadaud P, LaPergola CC, Dreibelbis C,Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Laurie A. Nommsen-Rivers L, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler RE, Spahn JM (USDA Pregnancy/Birth-24 months Technical Expert Committee 1). Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the lifespan: A systematic review. Am J Clin Nutr (Special Supplement)  109(Suppl 7):772S-799S. (2019)
  • Güngör D, Nadaud P, Dreibelbis C, LaPergola CC, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Laurie A. Nommsen-Rivers L, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler RE, Spahn JM (USDA Pregnancy/Birth-24 months Technical Expert Committee 1). Infant milk-feeding practices and childhood leukemia: A systematic review. Am J Clin Nutr (Special Supplement) 109(Suppl 7):757S-771S. (2019)
  • Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Laurie A. Nommsen-Rivers L, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler RE, Spahn JM (USDA Pregnancy/Birth-24 months Technical Expert Committee 1). Infant milk-feeding practices and celiac disease and irritable bowel disease and outcomes in offspring: A systematic review. Am J Clin Nutr (Special Supplement) 109(Suppl 7):838S-851S. (2019)
  • Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Laurie A. Nommsen-Rivers L, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler RE, Spahn JM (USDA Pregnancy/Birth-24 months Technical Expert Committee 1). Infant milk-feeding practices and diabetes outcomes in offspring: A systematic review. Am J Clin Nutr (Special Supplement) 109(Suppl 7):817S-837S. (2019)
  • Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Laurie A. Nommsen-Rivers L, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler RE, Spahn JM (USDA Pregnancy/Birth-24 months Technical Expert Committee 1). Infant milk-feeding practices and cardiovascular disease outcomes in offspring: A systematic review. 109(Suppl 7):800S-816S. (2019)
  • Delaney KM, Guillet R, Fleming RE, Yu R, Pressman EK, Vermeylen F, Nemeth E, O’Brien KO. Umbilical Cord Serum Ferritin Concentrations: Relation to Markers of Iron status and Erythropoiesis. J Nutr 149(3):406-415. (2019)
  • Best CM, Pressman EK, Queenan RA, Cooper E, O’Brien KO. Longitudinal changes in serum vitamin D binding protein and free 25-hydroxyvitamin D concentrations in a multiracial cohort of pregnant adolescents. J Steroid Chem and Molec Biol 186:79-88. (2019)
  • Steinl G, Whisner CM, Pressman EK, Cooper E, Groth SW, O’Brien KO. Patterns and correlates of self-reported physical activity in a cohort of racially diverse pregnant adolescents. J Pediatr Adoles Gynecology 32(1):51-6. (2019)
  • O’Brien KO, Abrams SA. Using stable isotope tracers to study bone metabolism in children. J Physiology Invited Review. J Physiol. 597(5):1311-9. (2019)

Lujan Lab

  • Kazemi M, Kim JY, Wan C, Xiong JD, Parry SA, Azziz R, Lujan ME. Comprehensive evaluation of disparities in cardiometabolic and reproductive risk between Hispanic and White women with polycystic ovary syndrome in the United States: a systematic reviewand meta-analysis. Am J Obstet Gynecol. 226(2):187-204.e15. doi:10.1016/j.ajog.2021.07.032. Epub 2021 Aug 9. (2022)
  • Vanden Brink H, Nosrati A, Ortiz-Flores AE, Tam A, Jarrett BY, Johnson L, Peppin AK,Lujan ME. Reliability and agreement of ultrasonographic measures of the ovarian stroma:impact of methodology. J Ultrasound Med 10.1002/jum.15917. (2021)
  • Oldfield AL, Kazemi M, Lujan ME. Impact of obesity on anti-mullerian hormone (AMH)levels in women of reproductive age. J Clin Med  10(14):3192. (2021)
  • Lin AW, Siscovick D, Sternfeld B, Schreiner P, Lewis CE, Wang ET, Merkin SS, WellonsM, Steffen L, Calderon-Margalit R, Cassano PA, Lujan ME. Associations of diet, physicalactivity and polycystic ovary syndrome in the Coronary Artery Risk Development inYoung Adults Women’s Study. BMC Public Health. 21(1):35. (2021)
  • Kazemi M, Kim JY, Parry SA, Azziz R, Lujan ME. Disparities in cardio-metabolic riskbetween Black and White women with polycystic ovary syndrome: a systematic reviewand meta-analysis. Am J Obstet Gynecol.  224(5):428-444.e8. (2021)
  • Vanden Brink H, Pea J, Lujan ME. Ultrasonographic features of ovarian morphologycapture nutritional and metabolic influences on the reproductive axis: implications forbiomarker development in ovulatory disorders. Curr Opin Biotechnol. 70:42-47. (2021)
  • Vanden Brink H, Pisch AJ, Lujan ME. A comparison of 2D and 3D ultrasonographicmethods for the evaluation of ovarian follicle counts and classification of ovarianmorphology. Fertil Steril 2021; 115(3):761-770.Article Commentary: Dewailly, D. Counting follicles to define polycystic ovarymorphology: should we change our way we do it? Fertil Steril. 115(3):605-606. (2021)
  • Ding A, Guerin A, Lujan ME, Velez MP. Polycystic ovary syndrome and incidentaldiagnosis of mosaic Turner Syndrome. J Obstet Gynaecol Can. 43(6):756-759. (2021)
  • Kazemi M, Hadi A, Pierson RA, Lujan ME, Zello GA, Chilibeck PD. Effects of DietaryGlycemic Index and Glycemic Load on Cardiometabolic and Reproductive Profiles inWomen with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Adv Nutr. 1;12(1):161-178. (2021)
  • Jarrett BY, Vanden Brink H, Oldfield AL, Lujan ME. Ultrasound Characterization ofDisordered Antral Follicle Development in Women with Polycystic Ovary Syndrome. J. Clin Endocrinol Metab. 105(11). (2020)
  • Kazemi M, Jarrett BY, Parry SA, Thalacker-Mercer A, Hoeger KM, Spandorfer SD, LujanME. Osteosarcopenia in reproductive-aged women with polycystic ovary syndrome: amulticenter case-control study. J Clin Endocrinol Metab. 105(9):e3400-14. (2020)
  • Pirotta S, Joham A, Grieger JA, Tay CT, Bahri-Khomami M, Lujan ME, Lim SS, MoranLJ. Obesity and the Risk of Infertility, Gestational Diabetes, and Type 2 Diabetes inPolycystic Ovary Syndrome. Semin Reprod Med. 38(6):342-351. (2020)
  • Kazemi K, Jarrett BY, Vanden Brink H, Lin AW, Hoeger KM, Spandorfer SD, Lujan ME.Obesity, insulin resistance, and hyperandrogenism mediate the link between poor dietquality and ovarian dysmorphology in reproductive-aged women. Nutrients. 12(7):1953 (2019)
  • Lin AW, Kazemi M, Jarrett BY, Vanden Brink H, Hoeger KM, Spandorfer SD, Lujan ME.Dietary and physical activity behaviors in women with polycystic ovary syndrome per thenew international evidence-based guideline. Nutrients. 2019, 11(11). pii: E2711.
  • Jarrett BY, Vantman N, Mergler RJ, Brooks ED, Pierson RA, Chizen DR, Lujan ME.Dysglycemia, not altered sex steroid hormones, affects cognitive function in polycysticovary syndrome. Journal of the Endocrine Society 3(10):1858-1868. (2019)
  • Jarrett BY, Vanden Brink H, Brooks ED, Hoeger KM, Spandorfer SD, Pierson RA, ChizenDR, Lujan ME. Impact of intra-individual variation on the ultrasonographic diagnosis ofpolycystic ovary syndrome. Fertility and Sterility. 112(5):939-946. (2019)
  • Kazemi M, Pierson RA, Lujan ME, Chilibeck PD, McBreairty LE, Gordon JJ, Serrao SB,Zello GA, Chizen DR. Comprehensive evaluation of type 2 diabetes and cardiovasculardisease risk profiles in reproductive-age women with polycystic ovary syndrome: a largeCanadian cohort. Journal of Obstetrics and Gynaecology Canada. 41(10):1453-1460. (2019)
  • Jarrett BY, Lin AW, Lujan ME. A commentary on the new evidence-based lifestylerecommendations for patients with polycystic ovary syndrome and potential barriers totheir implementation in the United States. Journal of the Academy of Nutrition and Dietetics. 119(2):205-210 (2019)

Place Lab

  • Buffenstein R (67 others including Place NJ) and Smith ESJ. (2021). The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole-rat biology. Biol Rev. 97:115-140. (2021)
  • McCormick K, Holekamp KE, Smale L, Weldele ML, Glickman SE and Place NJ. Sex differences in spotted hyenas. Cold Spring Harb Perspect Biol. Online ahead of print (2021)
  • Place NJ, Prado AM*, Faykoo-Martinez M, Brieño-Enriquez MA, Albertini DF and Holmes MM. Germ cell nests in adult ovaries and an unusually large ovarian reserve in the naked mole-rat. Reproduction. 161:89-98. (2020)
  • Zak A, Siwinska N, Elzinga S, Barker VD, Stefaniak T, Schanbacher Bj, Place NJ, Niedzwiedz A and Adams AA.  Effects of advanced age and pituitary pars intermedia dysfunction on components of the acute phase reaction in horses. Domest Anim Endocrinol. 72: 106476. (2020)
  • Daggett J, Cikanek S, Phair K, West G, Place NJ and Struthers JD. Pathology in Practice: Malignant Sertoli cell tumor in a Mexican gray wolf (Canis lupus baileyi). J Am Vet Med Assoc. 257:599-602. (2020)
  • Conley, A, Place NJ, Legacki EL, Hammond GL, Cunha GR, Drea CM, Weldele ML, and Glickman SE. Spotted hyaenas and the sexual spectrum: reproductive endocrinology and development. J Endocrinol. 247:R27-R44. (2020)
  • Prieto JM, Carney PC, Miller ML, Rishniw M, Randolph JF, Place NJ and Peterson ME. Shortterm biological variation of thyroid hormones in the serum of clinically healthy cats. Domest Anim Endocrinol. 71: 106389. (2020)
  • Zak A, Siwinska N, Elzinga S, Barker VD, Stefaniak T, Schanbacher Bj, Place NJ, Niedzwiedz A and Adams A. Effects of equine metabolic syndrome (EMS) on inflammation and acutephase markers in horses. Dom Anim Endocrinol. 72: 106448. (2020)
  • Place NJ, Cheraskin J-L, Hansen BS. Evaluation of combined anti-Müllerian hormone and progesterone concentrations for the diagnosis of ovarian remnant syndrome in dogs. J Am Vet Med Assoc. 254:1067-1072. (2019)

Weiss Lab

  • Pereira, C., Arroyo-Martinez, G.A., Guo, M.Z., Downey, M.S., Kelly, E.R., Grive, K.J., Mahadevaiah, S.K., Sims, J.R., Faça, V.M., Tsai, C., Schiltz, C.J., Wit, N., Jacobs, H., Clark, N.L., Freire, R., Turner, J.M.A, Lyndaker, A.M., Brieño-Enríquez, M.A., Cohen, P.E., Smolka, M.B., and Weiss, R.S. Multiple 911 complexes promote homolog synapsis, DSB repair and ATR signaling during mammalian meiosis. eLife 2022;11:e68677 DOI: 10.7554/eLife.68677 (2022)
  • Sims J.R., Faça V.M., Pereira C., Ascencao, C., Comstock, W., Badar, J., Arroyo-Martinez G.A., Freire, R., Cohen P.E., Weiss R.S., and Smolka, M.B. Phosphoproteomics of ATR Signaling in Mouse Testes. eLife 2022;11:e68648 (2022)
  • Loehr A.R., Pierpont T.M., Gelsleichter E., Galang, A.M.D., Fernandez, I.R., Moore, E.S., Guo, M.Z., Miller, A.D., and Weiss R.S. Targeting cancer stem cells with differentiation agents as an alternative to genotoxic chemotherapy for the treatment of malignant testicular germ cell tumors. Cancers 13:2045. (2021)
  • Lyndaker, A.M., Pierpont, T.M., Loehr, A.R., and Weiss, R.S. A genetically engineered mouse model of malignant testicular germ cell tumors. In: Bagrodia A., Amatruda J. (eds) Testicular Germ Cell Tumors. Methods in Molecular Biology, vol 2195. Humana, New York, NY. (2020)
  • Bloom, J.C., Loehr, A.R., Schimenti, J.C., and Weiss, R.S. Germline genome protection: implications for gamete quality and germ cell tumorigenesis. Andrology 7:516-526. (2019)

Kazemi Lab

  • Arab A, Khorvash F, Kazemi M, Heidari Z, Askari Gh. Effects of the Dietary Approaches to Stop Hypertension (DASH) diet on clinical, quality of life, and mental health outcomes in women with migraine: A randomized controlled trial. British Journal of Nutrition. https://doi.org/10.1017/S000711452100444X. (2021)
  • Kazemi M, Kim JY, Wan C, Xiong JD, Parry SA, Azziz R, Lujan ME. Comprehensive evaluation of disparities in cardiometabolic and reproductive risk between Hispanic and White Women with polycystic ovary syndrome in the United States: A systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. 2021; S0002-9378 (21): 00875–9. https://doi.org/10.1016/j.ajog.2021.07.032. (2021)
  • Hadi A, Asbaghi O, Kazemi M, Khadem Haghighian H, Pnatovic A, Ghaderi E, Abolhasani Zadeh F. Consumption of pistachio nuts positively affects lipid profiles: A systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition.  https://doi.org/10.1080/10408398.2021.2018569 (2021)
  • Oldfield AL, Kazemi M, Lujan ME. Impact of obesity on Anti-Müllerian Hormone (AMH) levels in women of reproductive age. Journal of Clinical Medicine 10(14), 3192; https://doi.org/10.3390/jcm10143192. (2021)
  • Hadi A, Arab A, Khalesi S, Rafie N, Kafeshani M, Kazemi M. Effects of supplementation with pro/synbiotics on anthropometric, glucoregulatory status, and lipid profile parameters in adults with metabolic syndrome: A systematic review and meta-analysis of randomized clinical trials. Clinical Nutrition 40 (7): 662–4673. https://doi.org/10.1016/j.clnu.2021.05.027. (2021)
  • Kazemi M, Kim JY, Parry SA, Azziz R, Lujan ME*. Disparities in cardio-metabolic risk profile between Black and White women with polycystic ovary syndrome: A systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. 2021; 224 (5): P428–444.E8. https://doi.org/10.1016/j.ajog.2020.12.019. (2021)
  • Kazemi M, Pierson RA, Parry SA, Kaviani M, Chilibeck PD*. Obesity, but not hyperandrogenism or insulin resistance, predicts skeletal muscle mass in reproductive-aged women with polycystic ovary syndrome: A systematic review and meta-analysis of 45 observational studies. Obesity Reviews. 2021; 22 (8): e13255. https://doi.org/10.1111/obr.13255. (2021)
  • Kazemi M, Hadi A, Pierson RA, Lujan ME, Zello GA, Chilibeck PD*.  Effects of dietary glycemic index and glycemic load on cardio-metabolic and reproductive profiles in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Advances in Nutrition. 12 (1): 161–178. https://doi.org/10.1093/advances/nmaa092. (2021)
  • Kazemi M, McBreairty LE, Chilibeck PD, Pierson RA, Chizen DR, Zello GA. Knowledge, attitudes, and barriers towards dietary pulse consumption in women with polycystic ovary syndrome participating in a multi-disciplinary lifestyle change intervention to improve women’s health. Sexes. 2 (1): 88–103. https://doi.org/10.3390/sexes2010008. (2021)
  • Hadi A, Pourmasoumi M, Kazemi M, Najafgholizadeh A, Marx W. Efficacy of synbiotic interventions on blood pressure: A systematic review and meta-analysis of clinical trials. Critical Reviews in Food Science and Nutrition. In Press. https://doi.org/10.1080/10408398.2021.1888278. (2021)
  • Jalili C, Kazemi M, Cheng H, Mohammadi M, Babaei A, Taheri E, Moradi S. Associations between exposure to heavy metals and the risk of chronic kidney disease: A systematic review and meta-analysis. Critical Reviews in Toxicology. In Press. https://doi.org/10.1080/10408444.2021.1891196. (2021)
  • Asbaghi O, Kashkooli S, Mardani M, Rezaei Kelishadi M, Fry H, Kazemi M, Kaviani M. Effect of green coffee bean extract supplementation on liver function and inflammatory biomarkers: A meta-analysis of randomized clinical trials. Complementary Therapies in Clinical Practice. 43: 101349. https://doi.org/10.1016/j.ctcp.2021.101349. (2021)
  • Shokri-Mashhadi N, Kazemi M, Saadat S, Moradi S. Effects of select dietary supplements on the prevention and treatment of viral respiratory tract infections: A systematic review of randomized controlled trials. Expert Reviews of Respiratory Medicine. 15 (6): 805–821. https://doi.org/10.1080/17476348.2021.1918546. (2021)
  • Babapour M, Mohammadi H, Kazemi M, Hadi M, Rezazadegan M, Askari G. Associations between serum magnesium concentrations and polycystic ovary syndrome status: A systematic review and meta-analysis. Biological Trace Element Research. 199 (4): 1297–1305. https://doi.org/10.1007/s12011-020-02275-9. (2021)
  • Kazemi M, Thalacker-Mercer AE, Lujan ME. Response letter to the editor from Smith et al.: Osteosarcopenia in reproductive-aged women with polycystic ovary syndrome: A multicenter case-control study. Journal of Clinical Endocrinology and Metabolism. 106 (3): e1500-e1501. https://doi.org/10.1210/clinem/dgaa670. (2021)
  • Kazemi M, Jarrett BY, Parry SA, Thalacker-Mercer AE, Hoeger KM, Spandorfer SD, Lujan ME. Osteosarcopenia in women with polycystic ovary syndrome: A multicenter case-control study. Journal of Clinical Endocrinology and Metabolism. 105 (9): e3400–e3414. https://doi.org/10.1210/clinem/dgaa426. (2020)
  • Kazemi M, Pierson RA, McBreairty LE, Chilibeck PD, Zello GA, Chizen DR. A randomized controlled trial of lifestyle intervention with longitudinal follow up on ovarian dysmorphology in women with polycystic ovary syndrome. Clinical Endocrinology (Oxford). 92 (6): 525–535. https://doi.org/10.1111/cen.14179. (2020)
  • Kazemi M, Jarrett BY, Vanden Brink H, Lin AW, Hoeger KM, Spandorfer SD, Lujan ME. Obesity, insulin resistance, and hyperandrogenism mediate the link between diet quality and ovarian morphology in reproductive-aged women. Nutrients. 12 (7): 1953. https://doi.org/10.3390/nu12071953. (2020)
  • Jalili C, Kazemi M, Taheri E, Mohammadi H, Boozari B, Hadi A, Moradi S. Exposure to heavy metals and the risk of osteopenia or osteoporosis: A systematic review and meta-analysis. Osteoporosis International. (31): 1671–1682. https://doi.org/10.1007/s00198-020-05429-6. (2020)
  • McBreairty LE, Kazemi M, Chilibeck PD, Gordon JJ, Chizen DR, Zello GA. Effect of a pulse-based diet and aerobic exercise on bone measures and body composition in women with polycystic ovary syndrome: A randomized controlled trial. Bone Reports. 100248. https://doi.org/10.1016/j.bonr.2020.100248. (2020)
  • Shirvani H1, Rahmati-Ahmadabad S, Kowsari E, Fry H, Kazemi M, Kaviani M. Effects of 2-week HMB-FA supplementation with or without eccentric resistance exercise on expression of some genes related to muscle protein turnover and serum irisin and IGF-1 concentrations. Gene. 760: 145018. (2020)
  • Kazemi M, Nematy M, Malekahmad M, Pahlavani N, Assadzadeh H, Ehsaei MR, Noroyzy A. Early enteral permissive underfeeding in critically ill young adults with traumatic brain injury: A single-blind randomized controlled pilot trial. Pilot and Feasibility Studies. https://doi.org/10.21203/rs.3.rs-53519/v1. (2020)
  • Kazemi M, McBreairty LE, Zello GA, Pierson RA, Gordon JJ, Serrao SB, Chilibeck PD, Chizen DR. A pulse-based and the Therapeutic Lifestyle Changes diets in combination with health counseling and exercise improve health-related quality of life in women with polycystic ovary syndrome: Secondary analysis of a randomized controlled trial. Journal of Psychosomatic Obstetrics and Gynecology41 (2): 144-153. https://doi.org/10.1080/0167482X.2019.1666820. (2019)
  • Kazemi M, Pierson RA, Lujan ME, Chilibeck PD, McBreairty LE, Gordon JJ, Serrao SB, Zello GA, Chizen DR. Comprehensive evaluation of type 2 diabetes and cardiovascular disease risk profiles in reproductive-age women with polycystic ovary syndrome: A large Canadian cohort. Journal of Obstetrics and Gynaecology Canada. 41(10): 1453-1460. https://doi.org/10.1016/j.jogc.2018.11.026. (2019)
  • Lin AW*, Kazemi M, Jarrett BY, Vanden Brink H, Hoeger KM, Spandorfer SD, Lujan ME. Dietary and physical activity behaviors in women with polycystic ovary syndrome per the new International Evidence-Based Guideline. Nutrients. 11 (11): 2711. https://doi.org/10.3390/nu11112711. (2019)
  • Askarpour M, Hadi A, Dehghani Kari Bozorg A, Sadeghi O, Sheikhi A, Kazemi M, Ghaedi E. Effects of l-carnitine supplementation on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Journal of Human Hypertension. 33 (10): 725-734. (2019)

Seandel Lab

  • N’Tumba-Byn, T, Martin, L.A., Do, E, Yamada, M, and SEANDEL, M. Loss of tyrosine kinase receptor EphB2 alters spermatogonial stem cell capacity. Biology of Reproduction. Apr 15;102(4):950-962. (2020)
  • Yamada, Y, Cai, W., Martin, L.A., N’Tumba-Byn, T, and SEANDEL M. Functional robustness of adult spermatogonial stem cells after induction of hyperactive Hras. PLoS Genetics. May 3;15(5):e1008139. (2019)
  • Finnerty, B.M., Moore, M.D., Verma, A., Aronova, A., Huang, S., Edwards, DP, Chen, Z, Seandel, M., Scognamiglio, T., Du, YN, Elemento, O., Zarnegar, R., Min, I.M., Fahey, T.J. UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors. Endocrine-Related Cancer. Apr 1;26(4):411-423. (2019)

Ren Lab

  • Ren YA (Corresponding author),  Monkkonen  T,  Lewis  MT,  Bernard  DJ,  ChristianHC,  Jorgez  CJ,  Moore  JA,  Landua  JD,  Chin  HM,  Chen  W,  Singh  S,  Kim  IS,  ZhangXH,  Xia  Y,  Philips  KJ,  MacKay  H,  Waterland  RA,  Ljungberg  MC,  Saha  PK,  HartigSM, Coll TF, Richards JS. (2019) S100a4-Cre-mediated deletion of Patched1 causeshypogonadotropic  hypogonadism:  role  of  pituitary  hematopoietic  cells  in  endocrineregulation. JCI Insight. July 2. PMID: 31265437 (2019)
  • Richards JS, Ren YA, Candelaria NC, Adams JE, Rajkovic A (2017). Ovarian thecacell  recruitment,  differentiation,  and  impact  on  fertility:  2017  update.  Endocrine Reviews. 2018 Feb 1; 39 (1): 1-20. PMID: 29028960 (2018)

Nikitin Lab

  • Dixon, D. and Nikitin, A. Yu. Female reproductive system. In Eds. Sundberg, J. P., Vogel, P, and Ward, J. M. Pathology of Genetically Engineered and Other Mutant Mice. Wiley, Hoboken, NJ. p. 403-430. (2022)
  • Fu, D.-J., Wang, L., Chouairi, F. K., Rose, I. M., Abetov, D. A., Miller, A. D., Yamulla, R. J., Schimenti, J. C., Flesken-Nikitin, A., and Nikitin, A. Yu. Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5-CD44+ cells. Nat. Commun. 11:84. doi.org/10.1038/s41467- 019-13847-2.  (2020)
  • Cheng, C. Y., Zhou, Z., Stone, M., Lu, B., Flesken-Nikitin, A., Nanus, D. M., and Nikitin, A. Yu. (2020). Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells. Oncogenesis 9:38 https://doi.org/10.1038/s41389-020-0222-3. (2020)
  • Rose, I. M., Bidarimath, M., Webster, A., Godwin, A. K., Flesken-Nikitin, A., and Nikitin, A. Yu. (2020). WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations. Sci. Rep. 10:9837(2020)
  • Yamulla, R. J., Nalubola, S., Flesken-Nikitin, A., Nikitin, A. Yu., and Schimenti, J. C. (2020). Functional screen of common mutated genes in High-Grade Serous Ovarian Carcinoma reveals TP53, PTEN and RB1 as core tumor suppressors in ovarian surface epithelial stem cells. Cell Reports, 32: 108086. (2020)
  • Fu, D.-J., De Micheli, A., Bidarimath, M., Ellenson, L. H., Cosgrove, B. D., Flesken-Nikitin, A., and Nikitin, A. Yu. (2020). Cells expressing PAX8 are the main source of homeostatic regeneration of adult endometrial epithelium and give rise to serous endometrial carcinoma. Dis. Model. Mech. Oct 30;13(10):dmm047035. doi: 10.1242/dmm.047035. (2020)

Comizzoli Lab

  • Comizzoli P, Loi P, Patrizio P, Hubel A. Long-term storage of gametes and gonadal tissues at room temperatures: the end of the ice age? J Assist Reprod Genet. Jan 4. (2022)
  • Macente BI, Fonseca-Alves CE, Magalhães GM, Tavares MR, Mansano CM, Mouttham L, Apparício M, Toniollo GH, Comizzoli P. Influence of vitrification device, warming protocol, and subsequent in vitro culture on structural integrity of testicular fragments from adult domestic cats. Biopreserv Biobank 2022, in press. (2022)
  • Comizzoli P, Power ML, Bornbusch SL, Muletz-Wolz CR. Interactions between reproductive biology and microbiomes in wild animal species. Animal Microbiome. 3, 1-3. (2021)
  • Amelkina O, Silva AMD, Silva AR, Comizzoli P. Transcriptome dynamics in developing testes of domestic cats and impact of age on tissue resilience to cryopreservation. BMC Genomics.  22:847. (2021)
  • Rowlison T, Comizzoli P. The Knowns and Unknowns about Epididymal Extracellular Vesicles in Different Animal Species. Adv Biol   Nov 23:e2101066. (2021)
  • Comizzoli P, Holt WV. Recent Progress in Spermatology Contributing to the Knowledge and Conservation of Rare and Endangered Species. Annu Rev Anim Biosci.  Nov 10. (2021)
  • Holt WV, Comizzoli P. Opportunities and Limitations for Reproductive Science in Species Conservation. Annu Rev Anim Biosci. Oct 26. (2021
  • Lee PC, Zahmel J, Jewgenow K, Comizzoli P. Desiccated cat spermatozoa retain DNA integrity and developmental potential after prolonged storage and shipping at non-cryogenic temperatures. J Assist Reprod Genet. Oct 5. (2021)
  • Rowlison T, Ottinger MA, Comizzoli P. Exposure to epididymal extracellular vesicles enhances immature sperm function and sustains vitality of cryopreserved spermatozoa in the domestic cat model. J Assist Reprod Genet. May 5. (2021)
  • Zainuddin ZZ, Sipangkui S. Kelana MF, Mohamed Tarmizi MR, Yap KC, Comizzoli P. Repeated evaluations of testes and semen characteristics in two binturongs (Arctictis binturong). Front Vet Sci. March 12. (2021)
  • Amelkina O, Comizzoli P. Initial response of ovarian tissue transcriptome to vitrification or microwave-assisted dehydration in the domestic cat model. BMC Genomics. 21:828. (2020)

Daugherity Lab

  • Relative Efficacy of AlfaxaloneVersus MS-222 Immersion Anesthesia for Rainbow Trout (Oncorhynchus mykiss), and Determination of Alfaxalone Tissue Residue Clearance Profile. SavsonDJ, Zenilman SS, SmithCR, Daugherity EK, SinghB, Getchell RG. J Am Assoc Lab Anim Sci. (Submitted, December 2021).
  • Comparing the Effects of Capromorelin and Mirtazapine on Appetite in New Zealand White Rabbits. DraperJMH,Savson DJ, LavinE,FeldmanE, SinghB,Martin-FloresM,Daugherity EK.J Am Assoc Lab Anim Sci. (Submitted, January, 2022).
  • Effects of Cisapride, Buprenorphine, and Their Combination on Gastrointestinal Transit in New Zealand White Rabbits. Feldman ER, Singh B, Mishkin NG, Lachenauer ER, Martin-Flores M, Daugherity EK. J Am Assoc Lab Anim Sci February 2021.
  • A Validated Smartphone-based Electrocardiogram Reveals Severe Bradyarrhythmias during Immobilizing Restraint in Mice of Both Sexes and Four Strains.  Labitt RN, Oxford EM, Davis AK, Butler SD, Daugherity EK. J Am Assoc Lab Anim Sci February 2021.
  • Kollias NK, Lauchenauer ER, Escobar A, Schuster CJ, Williams WO, Moore ES, Oxford E, Daugherity, EK.Intracoelomic Injection of Ethanol as an Alternative Method of Euthanasia in Zebra Finch (Taeniopygia guttata) and Chickens (Gallus gallus domesticus). J Am Assoc Lab Anim Sci. 2019. In Review.
  • Barnard KN, Alford-Lawrence BK, Buchholz DW, Wasik BR, LaClair JR, Yu H, Honce R, Ruhl S, Pajic P,Daugherity EK, Chen X, Schultz-Cherry SL, Aguilar HC, Varki A, Parrish CR. Modified Sialic Acids on Mucus and Erythrocytes Inhibit Influenza A Virus Hemagglutinin and Neuraminidase Functions. J Virol. 2020 Apr 16;94(9):e01567-19.
  • Holter MM, Garibay D, Lee SA, Saikia M, McGavigan AK, Ngyuen L, Moore ES,Daugherity E, Cohen P, Kelly K, Weiss RS, Cummings BP.Hepatocyte p53 ablation induces metabolic dysregulation that is corrected by food restriction and vertical sleeve gastrectomy in mice. FASEB J. 2020 Jan;34(1):1846-1858.
  • Moore ES,Daugherity EK, Karambizi DI, Cummings BP, Behling-Kelly E, Schaefer DMW, Southard TL, McFadden JW, Weiss RS.Sex-specific hepatic lipid and bile acid metabolismalterations in Fancd2-deficient mice following dietary challenge. J Biol Chem. 2019 Oct 25;294(43):15623-15637.
  • Moore, ES, Daugherity, EK, Singh, B, Mooneyhan, DE, Porri, TJ, Williams, WO.Position of charcoal air filtration canisters impacts the efficacy of anesthetic waste gas scavenging as assessed by a randomized trial. J Am Vet Med Assoc. 2019 Jun 15;254(12):1459-1465.
  • Pajic P, Pavlidis P, Dean K, Neznanova L, Romano RA, Garneau D,Daugherity E, Globig A, Ruhl S, Gokcumen O. Independent amylase gene copy number bursts correlate with dietary preference in mammals. Elife. May, 2019. 14;8:e44628.
  • Moore, ES,Cleland, AT,Williams, WO,Peterson, CM,Singh, B,Southard, TL,Pasch,B,Labitt, RN,Daugherity, EK.Comparing Phlebotomy by Tail Tip Amputation, Facial Vein Puncture, and Tail Vein Incision in C57BL/6 Mice by Using Physiologic and Behavioral Metrics of Pain and Distress. J Am Assoc Lab Anim Sci 56(3): 307-317.

Schimenti Lab

  • Singh, P., Fragoza, R,  Blengini, C., Tran, T., Pannafino, G., Al-Sweel, N.,  Schimenti, K.,Schindler, K.,  Alani, E., Yu, H., and Schimenti, J. MLH1/3 variants causinganeuploidy, pregnancy loss, and premature reproductive aging. Nature Comm, 12:5005.PMC8373927 (2021)
  • Bloom, J. and Schimenti, J. Sexually dimorphic DNA damage responses and mutationavoidance in the mouse germline. Genes & Development, 34:1637-1649. (2020)
  • Rinaldi, V., Bloom, J. and Schimenti, J. Signaling to TRP53 and TAp63 fromCHK1/CHK2 is responsible for elimination of most oocytes defective for eitherchromosome synapsis or recombination. Genetics, 215:373-8. PMC7268994. (2020)

Ruthig Lab

  • Ruthig VA, Yokonishi T, Friedersdorf MB, Batchvarova S, Hardy J, Garness JA, Keene JD, Capel B. A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells. Biol Reprod. 2021 Apr 1;104(4):861-874. doi: 10.1093/biolre/ioaa233. PubMed PMID: 33394034.
  • Huang Q, Cohen MA, Alsina FC, Devlin G, Garrett A, McKey J, Havlik P, Rakhilin N, Wang E, Xiang K, Mathews P, Wang L, Bock C, Ruthig V, Wang Y, Negrete M, Wong CW, Murthy PKL, Zhang S, Daniel AR, Kirsch DG, Kang Y, Capel B, Asokan A, Silver DL, Jaenisch R, Shen X. Intravital imaging of mouse embryos. Science. 2020 Apr 10;368(6487):181-186. doi: 10.1126/science.aba0210. PubMed PMID: 32273467.
  • Ruthig VA, Friedersdorf MB, Garness JA, Munger SC, Bunce C, Keene JD, Capel B. The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming. Development. 2019 Jul 25;146(19). doi: 10.1242/dev.175950. PubMed PMID: 31253634.
  • Riel JM, Yamauchi Y, Ruthig VA, Malinta QU, Blanco M, Moretti C, Cocquet J, Ward MA. Rescue of Sly Expression Is Not Sufficient to Rescue Spermiogenic Phenotype of Mice with Deletions of Y Chromosome Long Arm. Genes (Basel). 2019 Feb 12;10(2). doi: 10.3390/genes10020133. PubMed PMID: 30759861.
  • Ruthig VA, Nielsen T, Riel JM, Yamauchi Y, Ortega EA, Salvador Q, Ward MA. Testicular abnormalities in mice with Y chromosome deficiencies. Biol Reprod. 2017 Mar 1;96(3):694-706. doi: 10.1095/biolreprod.116.144006. PubMed PMID: 28339606.
  • Ruthig VA, Labrash S, Lozanoff S, Ward MA. Macroscopic demonstration of the male urogenital system with evidence of a direct inguinal hernia utilizing room temperature plastination. Anatomy. 2016 Dec;10(3):211-220. doi: 10.2399/ana.16.036. PubMed PMID: 28824276.
  • Yamauchi Y*, Riel JM*, Ruthig VA*, Ortega EA, Mitchell MJ, Ward MA. Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction. Science. 2016 Jan 29;351(6272):514-6. doi: 10.1126/science.aad1795. PubMed PMID: 26823431.
  • Yamauchi Y, Riel JM, Ruthig V, Ward MA. Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Formation and Function in Assisted Fertilization. PLoS Genet. 2015 Dec;11(12):e1005476. doi: 10.1371/journal.pgen.1005476. eCollection 2015 Dec. PubMed PMID: 26719889.
  • Ortega EA, Ruthig VA, Ward MA. Sry-Independent Overexpression of Sox9 Supports Spermatogenesis and Fertility in the Mouse. Biol Reprod. 2015 Dec;93(6):141. doi: 10.1095/biolreprod.115.135400. Epub 2015 Nov 4. PubMed PMID: 26536904.
  • Riel JM, Yamauchi Y, Sugawara A, Li HY, Ruthig V, Stoytcheva Z, Ellis PJ, Cocquet J, Ward MA. Deficiency of the multi-copy mouse Y gene Sly causes sperm DNA damage and abnormal chromatin packaging. J Cell Sci. 2013 Feb 1;126(Pt 3):803-13. doi: 10.1242/jcs.114488. Epub 2012 Nov 23. PubMed PMID: 23178944.

Smolka Lab

  • Caballero M, Ge T, Rebelo AR, Seo S, Kim S, Brooks K, Zuccaro M, Kanagaraj R, Vershkov D, Kim D, Smogorzewska A, Smolka M, Benvenisty N, West SC, Egli D, Mace EM, Koren A. Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation. Hum Mol Genet. Apr 8:ddac082. (2022)
  • Sims JR, Faça VM, Pereira C, Ascenção C, Comstock W, Badar J, Arroyo-Martinez GA, Freire R, Cohen PE, Weiss RS, Smolka MB. Phosphoproteomics of ATR signaling in mouse testes. Elife. 11:e68648. (2022)
  • Pereira C, Arroyo-Martinez GA, Guo MZ, Downey MS, Kelly ER, Grive KJ, Mahadevaiah SK, Sims JR, Faca VM, Tsai C, Schiltz CJ, Wit N, Jacobs H, Clark NL, Freire R, Turner J, Lyndaker AM, Brieno-Enriquez MA, Cohen PE, Smolka MB, Weiss RS.Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis. Elife. 11:e68677. (2022)
  • Sanford EJ, Smolka MB. Fe-NTA Microcolumn Purification of Phosphopeptides from Immunoprecipitation (IP) Eluates for Mass Spectrometry Analysis. Bio Protoc. 11(15):e4113. (2021)
  • Joiner AM, Phillips BP, Yugandhar K, Sanford EJ, Smolka MB, Yu H, Miller EA. Structural basis of TRAPPIII-mediated Rab1 activation. Fromme JC.EMBO J. 40(12):e107607. (2021)
  • Pellicanò G, Al Mamun M, Jurado-Santiago D, Villa-Hernández S, Yin X, Giannattasio M, Lanz MC, Smolka MB, Yeeles J, Shirahige K, García-Díaz M, Bermejo RCheckpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse. Mol Cell. 81(13):2778-2792. (2021)
  • Sanford EJ, Comstock WJ, Faça VM, Vega SC, Gnügge R, Symington LS, Smolka MB. Phosphoproteomics reveals a distinctive Mec1/ATR signaling response upon DNA end hyper-resection. EMBO J. 40(10):e104566. (2021)
  • Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB. In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep. 22(2):e51121. (2021)
  • Faca VM, Sanford EJ, Tieu J, Comstock W, Gupta S, Marshall S, Yu H, Smolka MB. Maximized quantitative phosphoproteomics allows high confidence dissection of the DNA damage signaling network. Sci Rep. 10(1):18056. (2020)
  • Bruhn C, Ajazi A, Ferrari E, Lanz MC, Batrin R, Choudhary R, Walvekar A, Laxman S, Longhese MP, Fabre E, Smolka MB, Foiani M. The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing. Nat Commun. 11(1):4154 (2020)
  • Dibitetto D, Sims JR, Ascenção CFR, Feng K, Kim D, Oberly S, Freire R, Smolka MB.Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling. NAR Cancer. 2(2):zcaa006. (2020)
  • Pereira C, Smolka MB, Weiss RS, Brieño-Enríquez MA. ATR signaling in mammalian meiosis: From upstream scaffolds to downstream signaling.
    Environ Mol Mutagen. 61(7):752-766. (2020)
  • Beck WHJ, Kim D, Das J, Yu H, Smolka MB, Mao Y. Glucosylation by the Legionella Effector SetA Promotes the Nuclear Localization of the Transcription Factor TFEB. iScience. 23(7):101300. (2020)
  • Shin JH, Lanz M, Smolka MB, Dörr T. Characterization of an anti-FLAG antibody binding protein in V. cholerae. Biochem Biophys Res Commun. 528(3):493-498. Epub 2020 Jun 3.(2020)
  • Waterman DP, Haber JE, Smolka MB. Checkpoint Responses to DNA Double-Strand Breaks. Annu Rev Biochem. 89:103-133. Epub 2020 Mar 16.(2020)
  • Yugandhar K, Wang TY, Leung AK, Lanz MC, Motorykin I, Liang J, Shayhidin EE, Smolka MB, Zhang S, Yu H. MaXLinker: Proteome-wide Cross-link Identifications with High Specificity and Sensitivity. Mol Cell Proteomics. 19(3):554-568. (2020)