Doug Antczak’s research program is focused on the health of horses, a passion of his from an early age. Through the Baker Institute’s Equine Genetics Center, the Antczak laboratory group has a long history of advancing basic knowledge and applying that knowledge in equine genetics, immunology, and reproduction.
In my lab, we seek to understand how defense systems operate across different organisms from bacteria to human. We study molecular mechanisms of non-coding RNA biogenesis and their function in regulation of gene expression. We use our knowledge of natural defense mechanisms to adapt them for genome and epigenome engineering applications. We study the link between chromatin and transcription and the post-transcriptional fate of RNA. We explore the hypothesis that chromatin marks and co-transcriptional events direct the fates of different transcripts. We work to understand the role that transposons (genetic parasites) play in evolution, normal development and diseases states such as cancer.
Dr. Bailey’s research is focused on the development and testing of evidence-based treatment protocols in veterinary reproductive practice. Clinically, he is particularly interested in management of high-risk pregnancy and parturition in animals.
Dr. Clark’s research focuses on the genetic basis of adaptive variation in natural populations, with emphasis on quantitative modeling of phenotypes as networks of interacting genes.
All things germ cells: germ cell development, gene regulation and meiosis.
Lipid regulation of calcium signaling in sperm function and fertilization.
I specialize in fertility preservation and germplasm cryo-banking for wild animal species, using model species that also are relevant to human reproductive medicine.
The Cosgrove laboratory studies development, aging and cancer in female productive tissues through single-cell and spatial transcriptomic dissection of mouse model systems.
Danko studies how gene expression patterns are encoded in DNA sequences, and how these patterns ultimately contribute to cell and organism level phenotypes, like infertility.
We use cell biology and genetic techniques to investigate germline chromatin biology, epigenetic inheritance, and reproductive aging. We focus on mechanisms of protein stability during reproductive aging, embryonic epigenetic plasticity, and evolutionary adaptations of conserved germline functions
